膜联蛋白Ⅰ在非小细胞肺癌中的表达及临床意义

摘要

Objective To explore ihe expression arid clinical of Annex in I (of Annex in I ) in non small cell lung cancer (Non-small cell lung cancer, NSCLC). Methods Immunohistoebemistry was used to measure the expression of 79 cases of non-small cell lung cancer Annexin I protein. Results In 79 cases of non-small cell lung cancer, 40 cases Aimexin I high expression (50.6%), squamous cell carcinoma expression for the envelope, adenoeareinoma of capsule exipression or envelope and the cytoplasm were expressed, but the envelope expression-based, which Annex in I expression level of non-small cell lung cancer patients with lymph node involvement (P=0.022, P < 0.05) related with gender, age, pathologic type, stage and there was no significant eoirelation (P < 0.05). Annexirt I patient with positive expression and engative expression of the patient time to disease progression (time to progression, TTP) relationship was statistically significant (P < 0.05). Conclusion Anexin .I expression is correlated with the occurrence of lung cancer development and metastasis, An-nexin I is highly expression in lung squamous cell carcinoma and lung adenoeareinoma, it might become the theoretical basis for early diagnosis and treatment of lung cancer.%目的 探讨膜联蛋白Ⅰ(Annexin Ⅰ)在非小细胞肺癌(Non-small cell lung cancer,NSCLC)中的表达及临床意义.方法 应用免疫组化法检测79例非小细胞肺癌中Annexin Ⅰ蛋白表达水平.结果 在79例非小细胞肺癌组织中,有40例为Annexin Ⅰ高表达(50.6%),鳞癌为包膜表达,腺癌为包膜表达或包膜与胞浆均有表达,但以包膜表达为主.Annexin Ⅰ表达水平与非小细胞肺癌患者的淋巴结受侵相关(P=0.022,P<0.05),而与性别、年龄、病理类型、分期均无明显相关性(P>0.05).Annexin Ⅰ阳性表达患者和阴性表达患者的疾病进展时间(time to progression,TTP)差异有统计学意义(P<0.05).结论 Annexin Ⅰ在肺鳞癌,肺腺癌中的表达均上调,可能与肺癌的发生、发展及转移相关,有望成为肺癌早期诊治的理论依据.