我院慢性乙型肝炎患者抗病毒治疗用药分析

摘要

目的 了解我院慢性乙型肝炎患者抗病毒治疗的用药情况,为临床合理用药提供参考.方法 采用随机抽样与回顾性调查方法,对我院门诊西药房2011年1~12月门诊诊断为慢性乙型肝炎的处方720张,按照药品分类、用药数量、用药频度(DDDs)以及联合用药情况进行统计分析.结果 在720张诊断为慢性乙型肝炎的处方中,以抗HBV药物使用为主,其中,核苷类抗病毒药物处方使用率为60.56%,DDDs最高的是阿德福韦酯,抗病毒方案以单独使用抗HBV药为主,占86.01%.结论 我院门诊慢性乙型肝炎患者的抗病毒治疗以核苷类药物为主,最常用的抗HBV药物是阿德福韦酯,用药较为合理.%Objective To investigate the usage situation of anti-HBV drugs in patients with chronic hepatitis B in our hospital,in order to guide the clinical rational drug use. Methods By random sampling method and retrospective survey,the total 720 chronic hepatitis B prescriptions in pharmacy department of our hospital from January to December 2011 were randomly selected and analyzed statistically,according to the kinds,amounts,DDDs and combination usage of drugs. Results Among 720 chronic hepatitis B prescriptions,the main used drugs were the anti-HBV drugs,the usage rate of nucleoside antiviral drug was 60.56%,among which DDDs of Adefovir Dipivoxil was ranked the first place. Single use anti-HBV drug was dominant (86.01%) in antiviral scheme. Conclusion Nucleosideucleotide analogues are the primary antiviral therapy drugs for patients with chronic hepatitis B in outpatients of our hospital. Adefovir Dipivoxil is the most widely used drug in anti-HBV drugs,which is basically rational used in our hospital.