健肝消脂颗粒治疗气滞血瘀型非酒精性脂肪性肝病的临床研究

摘要

目的：观察健肝消脂颗粒治疗气滞血瘀型非酒精性脂肪性肝病(NAFLD)的临床效果。方法选择2011年12月~2013年3月云南省中医医院就诊患者，将80例气滞血瘀型NAFLD患者随机分为两组，治疗组口服健肝消脂颗粒(5 g/次，3次/d)，对照组口服荷丹片(1.46 g/次，3次/d)，疗程均为3个月，观察治疗前后中医证候、肝脾CT比值、肝脏B超、血脂、肝脏功能酶学指标的改变。结果健肝消脂颗粒治疗NAFLD总效果较好；治疗组在改善证候总有效率方面优于对照组，差异有统计学意义(P<0.05)；治疗组在改善肝脏酶学总有效率方面优于对照组，差异有统计学意义(P<0.05)；治疗组在改善血脂总有效率方面与对照组比较，差异无统计学意义(P>0.05)；治疗组在改善腹部B超总有效率方面优于对照组，差异有统计学意义(P<0.05)；治疗组在升高肝脾CT比值方面与对照组比较，差异无统计学意义(P>0.05)。结论健肝消脂颗粒改善NAFLD患者中医证候、NAFLD严重程度、肝脏功能酶学指标、血脂指标效果较好，对NAFLD有较好的临床疗效；在改善肝脏酶学、肝脏B超、临床症状方面优于荷丹片，在改善肝脾CT比值及血脂作用方面与荷丹片疗效相当。%Objective To observe the clinical effect of Jiangan Xiaozhi Granule in the treatment of nonalcoholic fatty liver disease (NAFLD) of type of qi stagnancy and blood stasis. Methods Patients who took treatment in Yunnan Province Hospital of Traditional Chinese Medicine from December 2011 to March 2013 were chosen, of those 80 patients with NAFLD of type of qi stagnancy and blood stasis were randomly divided into two groups, the treatment group took Jiangan Xiaozhi Granule (once 5 g, three times per day) orally and the control group took Hedan Tablet (once 1.46 g, three times per day) orally. Both groups were treated for three months. The changes of traditional Chinese medicine (TCM) syndrome, the CT ratio of liver and spleen, liver B-type ultrasonic, liver enzyme, blood lipid and liver enzymology index before and after treatment were observed. Results Jiangan Xiaozhi Granule had good clinical effects on the treatment of NAFLD. On the total effective rate of improving TCM syndrome and liver enzymology, the treatment group was superior to the control group and the differences were statistically significant (P<0.05);on the total effective rate of improving blood lipid, the differences of the treatment group and the control group were not statistically significant (P > 0.05); on the total effective rate of improving TCM syndrome and abdominal B-type ultrasonic, the treatment group was higher than the control group, the differences were statistically significant (P<0.05); in increasing the CT ratio of liver and spleen, the differences of the treatment group and the control group were not statistically significant (P>0.05). Conclusion Jiangan Xiaozhi Granule plays good results in ameliorating TCM syndrome, NAFDL damage, liver enzymes and blood lipids indexes and has good clinical effects on NAFLD. Jiangan Xiaozhi Granule is superior to Hedan Tablet in improving liver enzymology and liver B-type ultrasonic, while it has relatively equal effects in improving CT ratio of liver and spleen and blood lipids compared to Hedan Tablet.