半夏泻心汤加减联合三联疗法治疗慢性胃炎的临床效果

摘要

目的：观察并探讨半夏泻心汤辨证施治联合三联疗法治疗慢性胃炎的临床效果。方法选择辽宁中医药大学附属医院2011年11月~2013年10月收治的127例慢性胃炎患者为研究对象,将其分为观察组(66例)、对照组(61例)。两组均给予兰索拉唑+克拉霉素+莫沙必利疗法,观察组辨证加服半夏泻心汤,4周为1个疗程,连续服用2个疗程,对比两组临床疗效与幽门螺杆菌(Hp)阴转率。结果服药2个疗程后,两组总体疗效构成不同(Z=2.389,P=0.017)；观察组与对照组痊愈率(31.8%比21.3%)、总体有效率(89.4%比77.0%)比较,差异均无统计学意义(字2=1.785,P=0.182；字2=3.500,P=0.061)；观察组与对照组Hp阴转率(95.2%比80.6%)比较差异有统计学意义(P=0.047)。两组患者服药期间未出现肝肾功能损害与明显药物不良反应。结论半夏泻心汤加减联合西药三联疗法治疗慢性胃炎较之单纯西药疗法更能有效保护胃黏膜,抑制Hp感染；中西医结合疗法治疗慢性胃炎效果更佳。%Objective To observe and explore the clinical efficacy of Banxia Xiexin Decoction combined with triple therapy in treatment of chronic gastritis (CG). Methods 127 CG patients in Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from November 2011 to October 2013 were selected as study objects, and divided into observation group (n = 66) and control group (n = 61), all patients were given Lansoprazole + Clarithromycin +Mosapride therapy, observation group was added Banxia Xiexin Decoction dialectically, 4 weeks for 1 treatment course, after treatment for 2 courses, clinical efficacy and Helicobacter pylori (Hp) negative conversion rate were compared be-tween 2 groups. Results After treatment for 2 courses, efficacy composition of the two groups was different (Z=2.389, P=0.017); cure rate (31.8%vs 21.3%), total effective rate (89.4% vs 77.0%) of observation group and control group had statistically significant differences (χ²=1.785, P=0.182;χ²=3.500, P=0.061); Hp negative conversion rate (95.2%vs 80.6%) of the two groups had a statistically significant difference (P= 0.047). Liver &kidney function damage and obvious adverse drug reactions were rarely seen in the two groups during medication. Conclusion Compared with sim-ple western medicine therapy, Banxia Xiexin Decoction dialectically combined with triple therapy can more effectively protect the gastric mucosa in treatment of CG, restrain Hp infection; combination of traditional Chinese and western medicine for treatment of CG with preferable outcome.