黄芩苷固体自乳化颗粒剂的制备

摘要

Objective To study the Baicalin Solid Self-emulsifying Granules preparation process. Methods Investigated by solubility, drawing pseudo-ternary phase diagram, and L9 (33) orthogonal experiment was given, to form a self-emul-sifying effect of self-emulsification time and particle size as indicator to select the best self-emulsifying prescription. Through the screening of the solid adsorbent material, and the determination of cumulative dissolution, the Baicalin sol-id self-emulsifying particles prescription was screened. Results The optimization of the best prescription for oleic acid ethyl ester-Tween 80-PEG400 was 2:7:6. Soluble starch and Baicalin S-SEDDS the mass ratio of 4:1, dissolution was 102.89% in 45 min. Conclusion Baicalin S-SEDDS is easy to prepare and its quality is stable. The dissolution of Baicalin S-SEDDS is improved.%目的：研究黄芩苷固体自乳化颗粒剂的制备工艺。方法通过溶解度考察、伪三元相图的绘制及L9(33)正交试验,以形成自乳化效果、自乳化时间和粒径的大小为指标,选择最佳自乳化处方。通过对固体吸附材料的筛选,累积溶出度的测定,筛选黄芩苷固体自乳化颗粒的最佳处方。结果最佳处方油酸乙酯-吐温(Tween)80-聚乙二醇(PEG)400的质量比为2颐7颐6,可溶性淀粉与黄芩苷固体自乳化释药系统(S-SEDDS)的质量比为4颐1,45 min溶出度达102.89%。结论黄芩苷S-SEDDS制备方法简单,稳定性好,可以提高药物的溶出度。