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Suitable composition for preparing spheroids by spheroidization process to produce a particulate material process to produce a spheroidized solid particulate dosage form and solid dosage form
Suitable composition for preparing spheroids by spheroidization process to produce a particulate material process to produce a spheroidized solid particulate dosage form and solid dosage form
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机译:用于通过球化工艺制备球体以制备颗粒材料的方法的合适组合物,以制备球化的固体颗粒剂型和固体剂型
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摘要
A particulate co-processed unattrited microcrystalline cellulose:hydrocolloid composition wherein the respective components are present in a weight ratio of from about 99:1 to 70:30. The composition is useful as a spheronizing agent for producing spheroids of uniform size and sphericity and having high drug loadings. The composition is produced by drying a slurry of the microcrystalline cellulose in an aqueous solution of the hydrocolloid. The preferred hydrocolloid is methylcellulose.
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