高压氧辅助治疗感音神经性聋的Meta分析

摘要

目的：评价高压氧辅助治疗感音神经性聋的效果。方法通过计算机检索国内外的数据库，如中国知网、万方、维普、PubMed、EBSCO、Sci Verse Science Direct等，设立纳入和排除标准，筛选符合条件的参考文献，并对文献的质量进行严格的评价和资料的提取，利用Revman 5.2软件对纳入文献的相关指标进行Meta分析。结果共纳入9篇文献，共1184例患者，其中治疗组(高压氧联合常规药物治疗组)465例，对照组(常规药物治疗组)719例。将纳入的患者按两种不同的疗效评价标准进行划分，每中评价标准分别按例数和耳数两个方面进行疗效评价。Meta分析结果显示不同的分析方式，治疗组无论是治愈率还是有效率均高于对照组(P<0.05)。结论高压氧对感音神经性聋具有较好的辅助治疗作用。%Objective To systematically assess the efficacy of sensorineural hearing loss with hyperbaric oxygenation for adjunctive treatment. Methods Search for literature in databases such as Hownet, Wanfang date, VIP, PubMed, EB-SCO, Sci Verse Science Direct, and some standards were set up. At the same time, the references were screened, and the methods were evaluated. Researchers went through strict evaluation and extraction against reference quality, and only the qualified references underwent Meta-analysis with Review Manager 5.2. Results A total of 9 studies with 1184 pooled patients were included, with 465 individuals in experiment group while 719 individuals in control group. There were two parts according to different standards, and analysis cure rate and total effective rate by number of patients and ears. Meta-analysis results implied that the efficacy of experiment group were better than control group in both cure rate and total effective rate in different respects (P<0.05). Conclusion Hyperbaric oxygenation has a great efficacy of sensorineural hearing loss for adjunctive treatment.