高剂量氟康唑治疗近平滑念珠菌感染的药学监护1例分析

摘要

Fluconazole,a three azole antifungal agent,is widely used in the treatment of Candida and Cryptococcal infections.However,with the increasingly prominent problem of Candida resistance,the choice of antifungal drugs and the use of dose has become a difficult point in clinical medication.This paper makes analysis for a case with parapsilosis Candidaemia treated with high dose Fluconazole,from the angle of disease diagnosis,treatment and the safety of high dose Fluconazole,combined with pharmaceutical car,and evaluates and intervenes the safety and rationality of drug use.The article provides reference for clinical rationly application of Fluconazole in the treatment of parapsilosis Candidaemia.%氟康唑是一种三唑类抗真菌药,广泛应用于念珠菌及隐球菌感染的治疗.随着念珠菌耐药问题的日益突出,抗真菌药物的选择及使用剂量的把握也成为临床用药的难点.本文从疾病诊断、治疗及高剂量氟康唑使用安全性等角度,结合药学监护,对1例使用高剂量氟康唑治疗近平滑念珠菌血症的病例进行分析,对用药安全性及合理性进行评估、干预,为临床合理应用氟康唑治疗近平滑念珠菌血症提供参考.