尿激酶溶栓治疗ST段抬高型心肌梗死的时间窗与疗效的相关性研究

摘要

Objective:To study the correlation between time window and effects of urokinase thrombolytic therapy in treating STEMI. Methods: STEMI patients in our hospital were enrolled and randomly divided observation group received thrombolytic therapy within 3 h after infarction and control group received thrombolytic therapy 3-6 h after infarction. Then myocardial cells necrosis index and ventricular diastolic function indexes were detected. Results: (1)cTnT, LDH,CK-MB levels of observation group were lower than those of control group and positively correlated with thrombolysis time; (2)E peak, E/A value, LVEF, LVEDD of observation group were higher than those of control group and negatively correlated with of thrombolysis time. Conclusion:short thrombolysis time has positive clinical value in treating STEMI for the myocardial necrosis is less and ventricular function recovery is better.%目的：研究尿激酶溶栓治疗ST段抬高型心肌梗死的时间窗与疗效的相关性。方法：将医院急诊收治的60例ST段抬高心肌梗死患者根据接受溶栓治疗的时间分为观察组(3 h内接受溶栓)和对照组(3～6 h接受溶栓)，检测心肌细胞坏死指标及心室舒缩功能指标，并分析与溶栓时间的相关性。结果：观察组患者的cTnT、LDH及CK-MB水平均低于对照组，与溶栓时间呈正相关，E峰、E/A值、LVEF及LVEDD均高于对照组，且与溶栓时间呈负相关。结论：心肌梗死发生后溶栓治疗时间越短，治疗后心肌细胞坏死越少、心室功能恢复越好，临床价值也越明显。