肝细胞癌超声造影与病理对照分析研究

摘要

Objective:To investigate the characteristic manifestations of ultrasound contrast imaging for hepatocellular carcinoma (HCC), and to take a contrast analysis by comparing it with pathological examination so as to provide reference for clinical diagnosis.Methods: 100 patients with space occupying lesion of hepatic were detected by pathological examination, and 90 cases of them were confirmed as primary hepatic carcinoma (PHC). And the 90 cases were divided into 3 group, high differentiation group (n=30), medium differentiation (n=40cases) and poorly differentiated group (n=20). The initial enhanced time, the initial clear time and the peak time of contrast agents among the three groups were analyzed by statistical method. And to take a contrast analysis to compare the characteristic manifestations of ultrasound contrast imaging with pathological examination.Results: The initial enhanced times of high differentiation, moderately differentiated and poorly differentiated groups of HCC were (19.13±2.51)s, (19.36±1.58)s and(18.43±2.28)s, respectively. The peak time of three groups were (35.16±2.25)s, (33.67±2.67)s and (31.79±2.63)s, respectively. The initial clear time were (103.4±2.56)s, (76.34±3.78)s and(49.34±3.56)s, respectively. There were no significant difference for peak time and the initial enhanced time among the three groups (F=1.637,F=1.241; P>0.05). And there was significant difference for initial clear the time among the three groups (F=15.637,P<0.05).Conclusion: The ultrasound contrast combines with pathological examination can provide reference for correctly early diagnosis and treatment of clinical hepatocellular carcinoma.%目的:探讨肝细胞癌(HCC)超声造影的特征性表现,并与病理结果进行对照分析,为临床诊断提供参考依据.方法:选取医院收治的100例肝占位性病变患者,采用超声造影对比脉冲序列成像技术进行检查,将所有患者按病理学检查不同分化程度的90例患者纳入本研究并分为高分化组(30例)、中分化组(40例)、低分化组(20例),并对3组造影剂的开始增强时间、开始廓清时间及达峰时间进行统计分析,并且将超声造影灌注特征与病理进行对照分析.结果:肝细胞癌高分化组、中分化组和低分化组的开始增强时间分别为(19.13±2.51)s、(19.36±1.58)s和(18.43±2.28)s;达峰时间分别为(35.16±2.25)s、(33.67±2.67)s和(31.79±2.63)s;开始廓清时间分别为(103.4±2.56)s、(76.34±3.78)s和(49.34±3.56)s;3组造影剂的开始增强时间及达峰时间比较,差异无统计学意义(F=1.637,F=1.241;P>0.05);3组廓清开始时间比较差异有统计学意义(F=15.637,P<0.05).结论:肝细胞癌超声造影与病理结果对照相结合,能为临床肝癌早期正确的诊断和治疗提供一定的参考依据.