探讨Z值诊断股骨近端骨质疏松的意义

摘要

目的 探讨应用Z值(Z-score)诊断绝经前妇女和小于50岁男性股骨近端骨质疏松症(Osteoporosis,OP)的意义.方法 在北京城区2744例正常人群中选择受检者,以股骨近端为测量点进行骨密度(Bone mineral density,BMD)测量观察在受试者中应用Z值对OP的诊断意义并与T值诊断OP的患病率比较.结果 受试者应用Z值诊断OP患病率较应用T值诊断明显降低,但男性在50岁以后出现患病率加速趋势.结论 应用Z值诊断绝经前妇女和小于50岁男性股骨近端OP可以避免过早的诊断OP,但其与骨折风险的相关性将有待于进一步研究.%Objective Aim To explore the diagnostic significance of Z score in proximal femur osteoporosis rnto pre-menopause women and men younger than 50 years old. Methods Proximal femur was chosen to rndetermine bone mineral density in the cohort of 2744 normal residents in urban area. Z score was obtained rnand compared with T value in the subjects. Results The incidence rate of osteoporosis diagnosed by Z score rnwas significantly lower than those by T value. However, the incidence becomes increasing for men older than rn50 years old. Conclusion Application of Z score for diagnosis of osteoporosis to pre-menopause women rnand men before 50 could reduce misdiagnosis of osteoporosis at early age, but the relationship to the risk of rnfracture remains to be determined.