A型肉毒毒素联合Lux1540-非剥脱点阵激光治疗额部皱纹的临床疗效和安全性观察

摘要

Objective To evaluate the effectiveness and safety of botulinum toxin type A injection andLux1540fractional laser on treatment of eye wrinkles.Methods Sixty patients with wrinkles,aged from 27 to65,were divided into three groups randomly.They were treated with botulinum toxin type A,Lux1540 fractional laser,or the combined therapy.Pictures were taken for each patient before treatment and immediate,at 7 daysand 1,3,6months after treatment,with which the results were evaluated.ResultsAt 3 to 7days after treatment,the dynamic wrinkles of patients treated with botnlinum toxin type A injection were alleviated. The static wrinkles of patients treated with Lux1540 fractional laser with or without botulinum toxin type A injection were alleviated right after the treatment.The dynamic wrinkles of those who treated with the combined therapy got better long—term effect.Conclusion It is effective and safe to treat eye wrinkles by using botulinum toxin type A injection and Lux1540 fractional laser combined therapy.%目的：探讨A型肉毒毒素联合Lux1540-非剥脱点阵激光：点阵激光治疗额头皱纹的临床疗效和安全性。方法将年龄27～65岁且寻求改善额头皱纹的门诊患者60例，随机平均分为3组，分别给予A型肉毒毒素注射，Lux1540-非剥脱点阵激光治疗，A型肉毒毒素注射联合Lux1540-非剥脱点阵激光治疗。每例患者在治疗前，治疗后即刻，治疗后7 d、1、3、6个月进行随访评价。结果单纯接受肉毒毒素注射的患者，在治疗后3～7 d开始出现动态皱纹的改善；接受Lux1540-非剥脱点阵激光以及A型肉毒毒素注射联合Lux1540-非剥脱点阵激光治疗的患者，术后即刻可观察到静态皱纹的改善，且肉毒毒素注射联合Lux1540-非剥脱点阵激光的患者，其动态皱纹的远期效果改善更加明显。结论 A型肉毒毒素联合Lux1540-非剥脱点阵激光，治疗可同时改善额部的动态皱纹和静态皱纹，并有明显的紧肤作用，且不良反应较轻，是进行额部年轻化治疗的理想方法。