目的：为了探讨慢性肾功能不全患者血层粘连蛋白(LN)和α1-微球蛋白(α1-MG)含量的变化及临床意义。方法：79例慢性肾功能不全患者以血肌酐(Cr)水平分为氮质血症组和尿毒症组，用放免分析法对全部患者血清LN和α1—MG进行检测。结果：氮质血症组与尿毒症组LN和α1—MG分别与对照组相比均有显著性差异(P<0.02)，尿毒症组血清α1-MG水平明显高于氮质血症组(P<0.01)，尿毒症组与氮质血症组血清LN水平无差异(P>0.05)。结论：血中LN和α1-MG水平测定可作为肾功能不全的实验室指标之一。%Objective:To investigate the clinical significance and alternation of Serum Laminin (LN) and α1 - microglobulin(α1 -MG) concentrations of the patients with chronic renal failure. Methods: 30 control subjects and 79 patients were involved in this study, 79 patients were divided into azotemia group and uremia group by serum crestitine, serum LN and α1 - MG concentrations were detected by radioimmunoassay. Results : Serum LN and α1 - MG in azotemia group and uremia group were remarkably higher than thase in normals respectively (P<0.02) ,serum α1 - MG in urmia group was significantly higher than that in azotemia group (P＜0. 01) ,While serum LN in uremia group was no different from that in azotemia group (P>0.05). Conclusions: Serum LN and α1 - MG may be one of the laboratory parameters of chronic renal failure.
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