Objective :To investigate the significance of soluble interleukin -2 receptor (sIL- 2R) and interleukin -6 (IL- 6) in plasma and bile in the diagnosis of acute rejection and bacterial infection in the early stage after liver transplantation. Methods: 20 patients undergoing orthotopic liver transplantation were included in our study.SIL- 2R and IL- 6 levels in plasma and bile were measured perioperatively by enzyme- linked immunoadsorbent assay. Results: Plasma sIL - 2R elevated prior to the pathological diagnosis of acute rejection and daily increase of IL6 in bile was more than 450 pg/ml ,which was seen in 3 of 4 patients prior to or at the onset of acute rejection. IL6 in plasma increased significantly when bacterial infection occurred, while slL- 2R in bile correlated with neither acute rejection nor bacterial infection. Conclusions: Measurements of sIL- 2R and IL- 6 may be useful in diagnosing acute rejection and bacterial injection during liver transplantation.%目的探讨血浆和胆汁中可溶性白细胞介素2受体(sIL-2R)和白细胞介素6(IL-6)对于肝移植术后早期急性排斥和细菌感染的诊断价值.方法对20例肝移植患者进行研究,测定围手术期血浆及胆汁中的sIL-2R和IL-6.结果急性排斥时,血浆sIL-2R在病理诊断前就可升高,胆汁IL-6在4例患者中3例日升幅大于450 pg/ml;细菌感染时,血浆IL-6可明显升高;胆汁sIL-2R在急性排斥和细菌感染时均无明显变化.结论sIL-2R和IL-6对于肝移植术后早期急性排斥和细菌感染的诊断有一定的价值.
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