A 26-year-old female presented with widespread erythema and superficial sterile pustules for 2 months and aggravated for 1 week. The patient had a psoriatic history for 13 years and she was at 28 week of pregnancy. Laboratory examination revealed hypoalbuminemia, leukocytosis and neutrophilia. Blood and pus were culture-negative for bacilli. The diagnosis of impetigo herpetiformis was made according to the clinical manifestations and laboratory parameters. The patient was treated with human immunoglobulin 20mg and ceftri-axone 1.0 g, once a day for 2 weeks with poor improvement and the recombinant human tumor necrosis factor-α receptor Ⅱ :IgG Fc fusion protein was used additionally, 25 mg, twice a week for 2 weeks. The treatment was effective and a healthy baby was delivered.%患者,女,26岁.全身泛发性红斑、脓疱2个月,加重伴高热1周.银屑病病史13年,妊娠28周.外周血白细胞及中性粒细胞偏高,血及脓疱细菌培养阴性,根据临床表现及辅助检查可诊断为疱疹样脓疱病.入院后给予人免疫球蛋白20 mg,头孢曲松1.0 g,1次/日,治疗2周效果不佳,加用重组人II型肿瘤坏死因子受体-抗体融合蛋白25 mg,2次/周,2周后好转出院,新生儿健康.
展开▼
