血栓通联合低分子肝素钠对急性脑梗死疗效观察

摘要

ObjectiveBy studying the thrombosis through joint Xue Shuan Tong Injection and low molecular heparin sodium injection for the treatment of acute cerebral infarction,clinical curative effect is significant,as to provide theoretical basis for the treatment of acute cerebral infarction.Methods Progressive cerebral infarction patients were randomly divided into control group and observation group. The control group on the basis of conventional western medicine therapy in treatment of acute cerebral infarction,with 14 d. Observation group on the basis of conventional western medicine treatment application blood clots injection 300 mg add saline 250 ml static drops,implement of intervention,once a day,a sharing of 14 days. At the same time combined low molecular heparin sodium 5 000 IU abdominal subcutaneous injection,12 hours once,with 7 d. Acute cerebral infarction, conventional treatment:oxygen intake,lower blood pressure, Lower blood sugar,Aspirin enteric-coated metformin hydrochloride(Baiasipilin)200 mg Po qn,Simvastatin(Shujiangzhi)10 mg Po qn,Pyrazole raschig temple ivdrip 8 g qd. According to the national institutes of health stroke scale (NIHSS)scores,mRS scale. Before treatment,after treatment 7 days,14 days each score again. Do 1 times respectively in the treatment of before and after the brain CT Assay liver function,renal function,blood routine, urine routine,stool routine,blood coagulation,etc. To closely observe during this condition changes.Results(1)compared with control group,observation group after treatment of 7 days,the 14 days,NIHSS score was lower than the control group,the clinical curative effect of observation group was more significant,compared with the control group,it had obvious difference(P<0.05). (2)compared with control group, observation group 7 days 14 days mRS score lower than the control group after treatment of acute cerebral infarction,clinical curative effect of observation group was significant,compared with the control group had obvious difference(P<0.05).(3) compared with control group, observation group noobvious difference was found between the frequency of the occurrence of adverse events.ConclusionThrombosis through joint low molecular heparin sodium injection for the treatment of acute cerebral infarction curative effect is distinct.%目的：通过研究血栓通注射液联合低分子肝素钠对急性脑梗死的治疗，观察其临床疗效，为急性脑梗死的治疗提供理论依据。方法将进展性脑梗死患者随机分为对照组和观察组。对照组在西医常规治疗基础上对诊断为急性脑梗死的患者进行治疗，共用14 d。观察组给予患者常规的西医治疗，并联合血栓通注射液300 mg溶解在250 ml生理盐水中静滴，1次/d，连用14 d，同时联合低分子肝素钠5000 IU腹壁皮下注射，1次/12 h，共用7 d。急性脑梗死常规治疗：吸氧，降压，降糖，阿司匹林肠溶片（拜阿司匹灵）200 mg po qn ，辛伐他汀（舒降之）10 mg po qn ，吡拉西坦8 g ivdrip qd。依照美国国立卫生研究院脑卒中量表（NIHSS），mRS量表，在治疗前，治疗后7 d，14 d各评分1次。在患者治疗前对患者行颅脑CT检查，抽血化验肝功能、肾功能、血凝、血常规、尿常规、大便常规、心电图等项，治疗后对患者进行复查，以便观察患者在用药期间的病情变化。结果（1）与对照组比较，观察组治疗后7 d、14 d NIHSS评分低于对照组，观察组对急性脑梗塞的临床疗效与对照组比较，差异具有统计学意义（P＜0.05）；（2）与对照组相比，观察组治疗后7 d、14 d mRS评分低于对照组，观察组对急性脑梗塞的临床疗效与对照组比较，差异具有统计学意义（P＜0.05）；（3）与对照组相比，观察组发生不良事件的频率无差异。结论血栓通注射液联合低分子肝素钠对急性脑梗死的治疗疗效好。