Objective To explore the effect of ceftriaxone sodium in in treatment of pregnancy syphilis and prevention of congenital syphilis. Methods 100 pregnant women with syphilis were selected into observation group(50 cases)and control group(50 cases). The patients in observation group were treated with ceftriaxone sodium,the control group patients were treated with benzathine penicillin. The incidences of congenital syphilis between two groups were compared. Results There were no significant difference between observation group and control group, the difference was not statistically significant(P>0.05). Conclusion Ceftriaxone sodium and benzathine penicillin have the same results in the prevention of congenital syphilis,for penicillin allergy persons,ceftriaxone sodium can be used as the medicine for preventing congenital syphilis. It can make more patients benefit.%目的：探讨头孢曲松钠治疗妊娠梅毒预防先天性梅毒的效果。方法选取我处接受治疗的梅毒孕妇100例，随机分为观察组和对照组，其中，观察组患者50例，以头孢曲松钠进行治疗。对照组患者50例，以苄星青霉素进行治疗。对比两组患者先天梅毒的发病率。结果观察组与对照组的组间无显著差异，结果不具有统计意义（P>0.05）。结论头孢曲松钠与苄星青霉素在预防先天性梅毒的效果中具有相同的结果，因此对于青霉素过敏者，可以使用头孢曲松钠作为预防先天性梅毒的药物，使得更多患者受益。
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