赖脯胰岛素与短效胰岛素强化治疗糖尿病的对比分析

摘要

Objective Compare efficacy and safety of insulin lispro and short-acting insulin in the intensive treatment of diabetes. Methods Choose 140 cases from Jun. 2009 to May. 2012 as the research object,random grouping. A group with short-acting insulin, B group were given insulin lispro,for 12 consecutive weeks. Observe 2 groups before and after treatment with FPG,2hPG,HbAlC levels,compare the differences hypoglycemia reaction. Results Compared with before treatment,2 groups with FPG,2hPG, HbAlC declined;Compared with group A,FPG,HbAlC of group B improved significantly bette,with significant statistical difference(P < 0.05). 2hPG has no statistical difference(P >0.05). During treatment of hypoglycemia incidence rate has no statistical difference(P >0.05). Conclusion Clinical curative effect of lispro insulin intensive treatment of diabetes is better.%　　目的对比赖脯胰岛素与短效胰岛素强化治疗糖尿病的有效性和安全性,以供临床借鉴和参考.方法 以2009年6月—2012年5月在该院接受强化治疗的2型糖尿病患者140例为研究对象,进行随机分组.A组给予短效胰岛素,B组给予赖脯胰岛素,连续治疗12周.观察两组患者治疗前后FPG、2hPG、HbAlC水平的变化,并比较治疗期间低血糖反应的差异.结果 与治疗前相比较,两组患者FPG、2hPG、HbAlC水平均有所下降；与A组相比较,B组FPG、HbAlC改善程度明显较好,差异有统计学意义(P < 0.05).两组患者2hPG比较,差异无统计学意义(P > 0.05).两组患者治疗期间低血糖发生率比较,差异无统计学意义(P > 0.05).结论 采用赖脯胰岛素强化治疗糖尿病临床疗效优于短效胰岛素,在患者经济条件许可的情况下可推广应用.