妊娠期高血压疾病患者尿蛋白成分与血清脂联素水平关系的研究

摘要

Objective To Investigate the relationship between pregnancy induced hypertension in patients with urinary protein and serum adiponectin levels. Methods With 185 cases of hypertensive disorders in pregnancy as the object of study, including 40 cases with hypertension, 89 patients with mild preeclampsia, 56 cases of severe preeclampsia; Select 110 normal third trimester pregnant women as control group. Use the methods of enzyme-linked immunosorbent (ELISA) to detect pregnant women serum adiponectin levels, at the same time detect urine protein components, compare two groups of serum adiponectin levels and the re-lationship between the urinary protein components. Results In patients with mild preeclampsia and cases of severe preeclampsia group macromolecules urinary protein components were higher than those in the control group, with the aggravation of disease have increasing trend (P<0.05); The serum adiponectin level in PIH group was significantly lower than that of the control group, and with the illness has obvious decreasing trend (P<0.05). Conclusion Pregnant women with pregnancy induced hypertension syn-drome urinary protein components and serum adiponectin levels are closely related, it is helpful for predicting the disease.%目的：探讨妊娠期高血压疾病患者尿蛋白成分与血清脂联素水平的关系。方法以185例妊娠期高血压疾病孕妇为研究对象，其中仅有高血压40例，轻度子痫前期89例，重度子痫前期56例；选取同期110例正常孕晚期孕妇为对照组。采用酶联免疫吸附法(ELISA法)检测孕妇血清脂联素水平，同时检测尿蛋白成分，比较两组血清脂联素水平、尿蛋白成分之间的关系。结果轻度子痫前期和重度子痫前期患者大分子尿蛋白成分明显高于对照组，随病情加重有增加趋势（P<0.05）；妊高征组血清脂联素水平明显低于对照组，并随着病情加重有明显的下降趋势（P<0.05）。结论妊高征孕妇尿蛋白成分与血清脂联素水平密切相关，对判断患者病情有一定价值。