Objective To study the effect of the implementation of nursing intervention in controlling hypoxic-ischemic en-cephalopathy in newborns. Methods 100 cases of newborns with hypoxic-ischemic encephalopathy admitted and treated in our hospital in recent two years and randomly divided into two groups, and they respectively adopted conventional nursing model and enhancing nursing intervention model, and the clinical symptom controlling situation and complication controlling effect difference were compared between the two groups. Results The changes of SOD and NDA in the observation group after nursing intervention were more obvious, the difference in the total improvement rate between the control group and the observation group was obvious, (88% vs 98%), and the incidence rates of intracranial hypertension, vomiting, glucopenia and convulsion complications in the observation group were obviously lower than those in the control group. Conclusion Enhancing nursing intervention can obviously improve the condition of hypoxic-ischemic encephalopathy in newborns and reduce the incidence rate of complications, which is worth promotion.%目的：研究对缺血缺氧性脑子在新生儿实施护理干预的效果。方法选取该院近两年收治的缺血缺氧性脑病新生儿共100例，随机分为两组，分别采用常规护理模式与加强护理干预模式，对比两组患儿临床症状控制状况以及并发症控制效果差异性。结果观察组患儿护理干预后SOD(超氧化物歧化酶)与MDA(丙二醛)分均变化更为明显。症状改善方面，对照组总改善率为88%，观察组总改善率为98%，组间差异有统计学意义。并发症方面，实施了护理干预的观察组在颅内高压、呕吐、低血糖、惊厥并发症发生率上均明显低于对照组。结论加强护理干预可显著改善新生儿缺血缺氧性脑病状况，降低并发症发生率，具有推广价值。
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