HBV宫内感染与孕期使用乙肝免疫球蛋白关系探讨

摘要

目的：探讨HBV宫内感染患者孕期应用乙肝免疫球蛋白的价值。方法选择2012年1月至2012年12月于我院收治的产检中检出乙型肝炎表面抗原阳性103例孕产妇，其中53例在孕期给予乙肝免疫球蛋白的孕妇及其新生儿作为观察组，其余50例未作特殊处理的孕妇及其新生儿作为对照组；比较产后两组新生儿HBV宫内感染的发生率情况。结果观察组新生儿HBV宫内感染的发生率在5％，较对照组20％明显降低，两组比较有显著差异性（P＜0．05）；且观察组中HbsAg（＋）3例，占5．7％，对照组HbsAg（＋）12例，占21．8％，两组比较有显著差异性（P＜0．05）。结论孕妇乙肝病毒感染可导致胎儿宫内感染，孕期注射乙肝免疫球蛋白及产后对新生儿进行联合免疫，可有效减少胎儿乙肝病毒感染的发生率，临床值得进一步研究应用。%Objective To discuss the value of application of hepatitis b immunoglobulin during pregnancy for patients with HBV intrauterine infection .Method 103 pregnant and lying-in women whose hepatitis b surface antigens were detected positive were chosen .Among them,53 women and their newborns were given hepatitis b immunoglobulins and marked as observation group while the other 50 women and their newborns were given no special treatments and marked as control group .Occur-rence rates of HBV intrauterine infection of newborns of the 2 groups were compared after deliveries.Result Occurrence rate of HBV intrauterine infection of newborns of observation group was 5% obviously lower than control group 20%(P<0.05);there were 3 cases of HbsAg( +)in observation group and accounted for 5.7% while 12 cases of HbsAg( +)in control group and accounted for 21.8%(P<0.05).Conclusion HBV infection of pregnant woman can lead to intrauterine infection of fetus.In-jection of hepatitis b immunoglobulin for pregnant woman during pregnancy and combined immunization for newborn can effectively reduce occurrence rate of HBV infec-tion.It needs to be further studied and applied.