Objective To study the clinical effect of emergency bedside blood perfusion in treatment of patients with acute severe drug poisoning. Methods 60 cases of patients with acute severe drug poisoning treated in our hospital from February 2012 to May 2013 were selected and randomly divided into study group and control group with 30 cases in each group. The control group were given internal routine treatment and the study group were given emergency bedside blood perfusion treatment, and the therapeutic effect of the two groups were analyzed and compared. Results 28 cases were cured and 2 cases died in the study group and 22 cases were cured and 8 cases died in the control group, the cure rate of the study group was significantly higher than that of the control group, both the coma time and hospital day in the study group were significantly lower than those in the control group, all patients had no complications and the data differences were compara-ble P<0.05. Conclusion For patients with acute severe drug poisoning, the use of emergency bedside blood perfusion treat-ment program has a more significant effect, which is conducive to remove toxins from the body, improve the cure rate of pa-tients and reduce the death rate and it is worthy of clinical promotion and application.%目的：探讨在急性重度药物中毒患者中采用急诊床边血液灌流治疗的临床效果。方法随机选取该院2012年2月—2013年5月间收治的60例急性重度药物中毒患者，随机分成研究组和对照组，各30例。对照组给予常规的内科治疗，研究组则采用急诊床边血液灌流治疗，对两组的治疗效果进行分析对比。结果研究组28例治愈，2例死亡，而对照组22例治愈，8例死亡，明显高于对照组治愈率，昏迷时间、住院天数等均明显低于对照组，患者均未出现并发症情况，数据差异具有统计学意义P<0.05。结论在急性重度药物中毒患者中采用急诊床边血液灌流治疗方案具有更显著的疗效，有利于清除患者体内毒素，改善患者的治愈率，减少死亡率，值得临床推广及应用。
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