目的：探讨女性甲状腺癌的病理特点以及预后影响因素。方法整群选取2008年1月—2012年1月,该院收治的女性甲状腺癌患者148例,回顾分析其临床病理特点以及预后影响因素。结果病理检查显示133例(89.9%)甲状腺乳头状癌(PTC),6例(4.1%)为滤泡状癌(FTC),3例(2.0%)为髓样癌(MTC),6例(4.1%)为未分化癌(ATC)；病理分期Ⅰ~Ⅱ期占45.3%,Ⅲ~Ⅳ期占54.7%；27例(18.24%)为周围组织侵犯,9例(6.1%)为远处转移,10例(6.76%)对侧甲状腺转移,56例(37.84%)颈部淋巴结转移；1年、3年、5年生存率依次为97.3%、93.2%、83.8%；年龄、病理床分期、病理类型、淋巴结转移、远处转移以及周围组织侵犯均是影响临床预后的重要因素(P<0.05)。结论女性甲状腺癌存在病理分期晚、病理分型差、淋巴结转移、远处转移及局部侵犯率高等不良预后因素,早期影像学检查对临床治疗具有指导意义。%Objective To investigate the pathological features and the prognostic factors of female patients with thyroid cancer. Methods 148 cases of female patients with thyroid cancer in our hospital between January 2008 and January 2012 were collected, the clinical and pathological characteristics and prognostic factors were reviewed and analyzed. Results Pathological examination showed that 133 cases (89.9%) were papillary thyroid cancer (PTC), 6 patients (4.1%) were follicular cancer (FTC), 3 cases (2.0%) were medullary cancer (MTC), 6 patients (4.1%) were undifferentiated cancer (ATC);Pathological stageⅠ-Ⅱperiod accounted for 45.3%,Ⅲ -Ⅳstage accounted for 54.7%;27 cases (18.24%) of surrounding tissue invasion, 9 cases (6.1%) of distant metastases, 10 cases (6.76%) of contralateral thyroid metastases, 56 cases (37.84%) of cervical lymph node metastasis; 1-year, 3-year, 5-year survival rates were 97.3%, 93.2%, 83.8%; age, pathological bed staging, histological type, lymph node metastasis, distant metastasis and surrounding tissue invasion were the mportant clinical prognostic factors (P<0.05). Conclusion Female patients with thyroid cancer have adverse prognostic factors of Late staging, pathological type differential, high lymph node metastasis, distant metastasis and local invasion rate, early imaging has important guiding significance for clinical treatment.
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