目的：探讨儿科临床应用中阿奇霉素的不良反应。方法随机选取2012年10月-2014年10月该院收治的180例儿科患者临床资料，随机分为A组、B组，各90例。A组口服阿奇霉素治疗，B组选取静脉滴注阿奇霉素治疗，对比两组患儿临床不良反应。结果 A组胃肠道反应、发热、过敏性休克、过敏性皮疹等不良反应发生率分别为11.11%、7.78%、5.56%、2.22%，分别与B组的13.33%、10.00%、6.67%、4.44%对比，差异无统计学意义(P>0.05)。结论阿奇霉素在儿科临床应用中的不良反应包括胃肠道反应、过敏性休克、过敏性皮疹、发热等症状，在临床治疗中应该合理选取静脉滴注及口服方式，以降低不良反应发生率，确保较高的临床疗效。%Objective To investigate the adverse reactions of Azithromycin applied to Department of Pediatrics clinically. Methods The clinical data of 180 pediatric patients admitted in our hospital from October 2012 to October 2014 were selected. And the pa-tients were divided into group A and group B with 90 patients in each group. Group A were treated by Azithromycin orally, group B were treated by intravenous drip of Azithromycin. And the clinical adverse reactions were compared between the two groups. Results The incidence of gastrointestinal reaction, fever, anaphylactic shock, allergic rash and other adverse reactions in group A was 11.11%, 7.78%, 5.56%, 2.22%, respectively, and that in group B was 13.33%, 10.00%, 6.67%, 4.44%, respectively, with no statistically significant difference (P>0.05). Conclusion The adverse reactions of Azithromycin applied to Department of Pediatrics clinically mainly include gastrointestinal reaction, anaphylactic shock, allergic rash and fever and other symptoms. In order to re-duce the incidence of adverse reactions and ensure high clinical curative effect, oral or intravenous administration of Azithromycin in clinical treatment should be selected rationally.
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