非典型抗精神病药物对女性精神分裂症患者甲状腺激素水平的影响

摘要

Objective To investigate the effect of atypical anti psychotic drugs on thyroid hormone levels in female patients with schizophrenia. Methods Through January 2012 to July 2014 in our hospital for treatment of 72 cases of patients with schizophrenia group, A group were treated with didgeridoo, Capitoline patients in group B, group C patients Implementation olanzapine treatment, choose the same period of 50 health examination staff. Comparison of serum thyroid hormone levels were observed difference between groups. Results Patients with thyroid hormone treatment and control group was not statistically significant (P> 0.05), in patients with T4, T3 level was significantly decreased after treatment with treatment, TSH levels were significantly increased, the difference was statistically significant (P <0.05). Conclusion The atypical anti psychotics may lead to changes in serum thyroid hormone levels in patients with schizophrenia, the clinical course of treatment for thyroid hormone levels should be regularly tested.%目的：探讨非典型抗精神病药物对女性精神分裂症患者甲状腺激素水平的影响。方法通过对2012年1月—2014年7月在该院进行治疗的72例精神分裂症患者进行分组，A组患者给予利培酮治疗，B组患者应用氯氮平治疗，C组患者实施奥氮平治疗，选取同期进行健康体检的50名人员。观察比较各组血清甲状腺激素水平差异。结果治疗前患者甲状腺激素与对照组比较差异无统计学意义（P＞0.05），治疗后患者T4、T3水平同治疗前比较明显下降，TSH水平明显增加，差异具有统计学意义（P＜0.05）。结论非典型抗精神病药物可导致精神分裂症患者血清甲状腺激素水平变化，在临床治疗过程中应定期对甲状腺激素水平进行检测。