Objective To observe the therapeutic effect of buprenorphine transdermal patch in the degenerative spine relat-ed pain in.Methods Randomly selected in January 2015 to December 2015 to our hospital was performed in 100 cases of patients with degenerative disease of the spine for the treatment of pain associated, were randomly divided into observation group and control group, each of 50 cases, the control group received tramadol hydrochloride for treatment, the observation group given buprenorphine transdermal treatment, the treatment in the two groups were observed before and after treatment, 24 h, 72 h, 7 d and 14 d resting state and activity state changes in pain and treatment of adverse reactions occurred. Re-sults After treatment 72 h, 7 d, 14 d, observe group in the resting state and active state of VAS score respectively (1.94 ± 0.78) scores, (2.52 ± 0.84 scores); (1.14 ± 0.54) scores, (1.85 ±0.77) scores; (0.81 ± 0.30) scores, (1.52 ±0.64) scores were significantly lower than those of the control group, and the difference is statistically significant. There was no significant dif-ference in the incidence of adverse reactions between the two groups. Conclusion Buprenorphine transdermal patch has good therapeutic effect on spinal degeneration related pain, and high safety.%目的：探讨丁丙诺啡透皮贴在脊柱退变相关疼痛中的治疗作用。方法随机选择2015年1—12月该院进行脊柱退变相关疼痛治疗的患者100例,随机分为观察组和对照组各50例,对照组给予盐酸曲马多进行治疗,观察组给予丁丙诺啡透皮贴进行治疗,观察两组患者治疗前、治疗后24 h、72 h、7 d以及14 d静息状态和活动状态下疼痛变化情况以及治疗中不良反应发生情况。结果治疗后72 h、7 d、14 d,观察组在静息状态和活动状态下的VAS评分分别为(1.94±0.78)分、(2.52±0.84)分；(1.14±0.54)分、(1.85±0.77)分；(0.81±0.30)分、(1.52±0.64)分均明显低于对照组,且差异有统计学意义。两组患者不良反应发生率差异无统计学意义。结论丁丙诺啡透皮贴对于脊柱退变相关疼痛具有较好的治疗作用,且安全性高。
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