急性肾衰竭患者血清胱抑素C水平与病情危重程度相关性研究

摘要

Objective To explore the correlation between the serum cystatin C levels in patients with acute renal failure (ARF) and the disease severity. Methods Convenient selection a total of 150 cases of patients with ARF as the research objects who were cured in our hospital between June 2013—June 2015 and 30 cases of healthy persons as control group were selected. The concentration of cystatin C and serum creatinine (Scr) in these patients were detected by using ELISA method. According to the acute physiology and chronic health score III (APACHE III) system, patients with ARF were divid-ed into five groups. The relationship between cystatin C level and APACHE III score was analyzed. Results Cystatin C level in ARF patients was significantly higher than that in control group [(3.1±0.8) mg/L vs (1.1±0.2)]. It was positively correlated with APACHE III score. Conclusion Elevated serum C cystatin level can be used as a biological indicator to judge the severity of ARF, and cystatin C can be used to monitor the condition of ARF.%目的：探讨急性肾衰竭(acute renal failure, ARF)患者血清胱抑素C(cystatin C)水平与病情危重程度相关性。方法方便选取郑州颐和医院该院从2013年6月—2015年6月收治的150例ARF患者,30名健康体检者作对照组,使用ELISA法检测受试者中血清cystatin C和血肌酐(serum creatinine, Scr)浓度；根据急性生理与慢性健康状况评分Ⅲ(acute physiology and chronic health evaluation Ⅲ, APACHE Ⅲ)系统评分将ARF患者分为5组(每组30例)并分析cystatin C水平与5组患者的APACHEⅢ评分的关系。结果 ARF患者血清cystatin C水平显著高于对照组[(3.1±0.8) vs (1.1±0.2) mg/L],并与APACHEⅢ评分呈正相关。结论血清cystatin C水平升高可以作为判断ARF病情加重的一项生物指标,可以使用cystatin C对急性肾损伤病情进行监测。