亚氯酸盐对三代大鼠的胚胎毒性

摘要

The embryo toxicity of chlorite on Wistar rat was investigated through a three-generation test. No teratogenic effect, abnormal viscera and skeleton was observed on fetal rats. Exposure to 120 and 360mg/L chlorite for long term led to decreased body weights for the pups. No observed adverse effect level of chlorite on fetal rat was determined at 30mg/L, and the maximum contaminant level goal of chlorite in drinking water could be deduced as l.lmg/L.%通过三代染毒实验,研究了亚氯酸盐对Wistar大鼠的长期胚胎毒性.结果表明:亚氯酸盐对胎鼠的内脏、骨骼发育无影响,没有表现出致畸作用,但长期摄入120,360mg/L亚氯酸盐可导致胎鼠体重减轻.亚氯酸盐对胎鼠的无明显副作用剂量为30mg/L,由实验结果可推算饮用水中亚氯酸盐最大污染水平目标值推算为1.1mg/L.