全麻诱导时不同静脉给药顺序对芬太尼诱发咳嗽的影响分析

摘要

Objective Effects of analgesia effect of different sequences of intravenous administration on fentanyl-induced cough during induction of general anesthesia. Methods A retrospective analysis of 120 cases, aged 19~71 yr, weighing 41~89 kg, of ASA physical status ⅠorⅡ, scheduled for elective surgery under general anesthesia, were equally randomized to 2 groups using a random number table: fentanyl-propofol group (group FP) and propofol- fentanyl group (group PF), in FP group. fentanyl 3μg/kg was injected intravenously over 3 s, and then propofol1.5 mg/kg was injected intravenously, in PF group, propofol 1.5 mg/kg was injected intravenously, and then fentanyl 3μg/kg was injected intravenously over 3 s. The development, Intensity and onset time of cough were record within 1 min after fentanyl injection. Results Compared with FP group, the incidence of cough was signiifcantly decreased (P<0.05), and no signiifcant change was found in the intensity and onset time of cough in PF group (P>0.05).Conclusion Administration in the propofol-fentanyl sequence can reduce the development of fentanyl-propofol cough as compred with that in the fentanyl-propofol sequence during induction of general anesthesia.%目的：分析评价全麻诱导时不同静脉给药顺序对芬太尼诱发咳嗽的影响。方法回顾性分析我科全麻下择期手术患者120例，年龄19～71岁，体重41～89 kg，ASA分级Ⅰ或Ⅱ级，随机均分为芬太尼-异丙酚组（FP组）和异丙酚-芬太尼组（PF组），每组患者均为60例， FP组静脉注射芬太尼3μg/kg，在3 s内注射完，随后静脉注射异丙酚1.5 mg/kg，PF组静脉注射异丙酚1.5 mg/kg，随后静脉注射芬太尼3μg/kg，在3 s内注射完，记录注射芬太尼后1 min内咳嗽的发生情况和出现时间。结果与FP组比较，PF组咳嗽发生率降低（P＜0.05），咳嗽出现时间差异无统计学意义（P＞0.05）。结论与芬太尼-异丙酚给药比较，异丙酚-芬太尼给药可减少全麻诱导时芬太尼诱发的咳嗽。