目的：比较超声引导下右美托咪定与芬太尼用于经皮微波消融治疗肝癌麻醉的效果。方法选取2013年2月～2014年8月我院经皮微波消融治疗的肝癌患者37例，将其随机分为右美托咪定组（n=19）和芬太尼组（n=18），右美托咪定组用微量泵注射0.3μg/kg右美托咪定，芬太尼组静脉注射0.8μg/kg的芬太尼，静脉维持麻醉至经皮微波消融治疗结束前的2～5 min，超声引导定位后，右美托咪定组用0.4 mg/kg的丙泊酚诱导麻醉，芬太尼组用1.5 mg/kg的丙泊酚诱导麻醉，维持至经皮微波消融治疗结束。结果芬太尼组患者的心率和血压在经皮微波消融治疗前后的变化大于右美托咪定组患者，差异有统计学意义，P＜0.05,两组患者的总满意度比较，差异有统计学意义，P＜0.05。结论经皮微波消融治疗肝癌麻醉中右美托咪定对患者的生命体征改变小，满意度高。%ObjectiveTo compare the anesthetic effect between dexmedetomidine and fentanyl in ultrasonically guided percutaneous microwave coagulation therapy for hepatocellular carcinoma. Methods 37 liver cancer patients with percutaneous microwave ablation in our hospital were randomly selected into dexmedetomidine group (n=19), treated with 0.3 μg/kg dexmedetomidine by micro pump, and fentanyl group (n=18) with 0.8 μg/kg of fentanyl for intravenous injection. The intravenous anesthesia were maintained to 2~5 min before the end, after ultrasound-guided localization, the patients in dexmedetomidine group were treated with 0.4 mg/kg propofol anesthesia induction, fentanyl group were treated with 1.5 mg/kg propofol anesthesia induction, which were maintained until the end of percutaneous microwave coagulation therapy.ResultsThe changes of heart rate and blood pressure after percutaneous microwave coagulation therapy in fentanyl group were greater than the fentanyl group signiifcantly (P<0.05), the difference of total satisfaction between two groups was signiifcant (P<0.05).ConclusionDuring the anesthesia of percutaneous microwave coagulation therapy of liver cancer, the change of patient's vital signs is small in the dexmedetomidine group, the degree of satisfaction is high, it is worthy to be applied.
展开▼
