不同剂量生长抑素治疗急性重症胰腺炎的疗效观察

摘要

目的：观察不同剂量的生长抑素治疗急性重症胰腺炎的疗效。方法选取2014年1月～2015年12月我院收治的60例急性重症胰腺炎患者为研究对象，随机分为低剂量组和高剂量组。每组各30例。两组在相同基础上，采用不同剂量生长抑素静脉滴注，低剂量组予生长抑素6 mg/d，高剂量组予生长抑素12 mg/d，疗程均为7天。比较两组治疗效果。结果高剂量组住院时间短于低剂量组，假性囊肿发生率低于低剂量组，差异均具有统计学意义（P＜0.05）。高剂量组急性呼吸窘迫综合征发生率、急性肾衰竭发生率、死亡率与低剂量组对比，差异无统计意义（P＞0.05）。结论12 mg/d的生长抑素治疗急性重症胰腺炎的疗效较为显著，具有能够降低并发症，改善炎症水平，缩短住院时间等优点。%Objective To observe the curative effect of different doses of somatostatin in the treatment of severe acute pancreatitis.Methods From January 2014 to December 2015 in our hospital, 60 cases of severe acute pancreatitis patients as the research object and were randomly divided into low dose group and high dose group, 30 cases in each group. Two groups on the same basis, intravenous somatostatin infusion of different doses, the low dose group was treated with somatostatin 6 mg/d, high dose group was treated with somatostatin 12 mg/d, QD for 7 days. The therapeutic effect was compared between two groups.Results High dose group was shorter than the low dose group,pseudocyst incidence is lower than the low dose group,P < 0.05. Acute respiratory distress syndrome incidence, the incidence of acute renal failure and mortality were no signiifcant difference between,P > 0.05.Conclusion Signiifcant curative effect of somatostatin 12 mg/d in the treatment of severe acute pancreatitis,can reduce complications, improve the level of inlfammation, shorten the hospitalization time and other advantages.