SYNTHESIS AND ANTITUMOR ACTIVITY OF PEPTIDYL-N^2-HYDROXYMETHYL-5-FLUOROURACIL

摘要

Six hydrophobic peptidyl and four amino acid (L-Val, L-Leu,L-Phe, L-Gly) derivatives of 5-fluorouracil(5-FU) were synthesized.The structure of these compounds were characterized by ~1H-NMR, IR,UV spectra and elemental analysis. The antitumor activity was test-ed against EAC cells in vitro.