Mn-mediated reductive C(sp3)–Si coupling of activated secondary alkyl bromides with chlorosilanes

摘要

The construction of secondary alkylsilanes is a challenging subject in the synthetic community.The cross-coupling provides a practical solution to address this problem,but it typically relies on organometallic species.Herein,we report an Mn-mediated reductive C(sp^(3))-Si coupling to synthesize these compounds from alkyl and silyl electrophiles.This approach avoids the requirement for activation of Si-Cl by transition metals and thus allows for the coupling of various common chlorosilanes.The reaction proceeds under mild conditions and shows good functional group compatibility.The method offers access toα-silylated organophosphorus and sulfones with a scope that is complementary to those obtained from the established methods.