Supramolecular interaction controlled and calix4arene ligand assisted Pd-catalyzed C(sp3)-H arylation of aliphatic aldehydes

摘要

A calix[4]arene ligand assisted directβ-C-H arylation of tertiary aliphatic aldehydes has been developed via a Pd-catalyzed C(sp3)-H functionalization process.This strategy exhibited good functional group compatibility and C-H bond site-selectivity.Mechanism studies have shown that both synergistic effect and cationic-πsupramolecular interaction between calixarene cavity and transition-metal catalytic center may play an important role in this catalytic cycle.This complementary method would be used in organic and medical chemistry due to the importance of tertiary aliphatic aldehydes.