A green multicomponent synthesis of bioactive pyrimido4,5-bquinoline derivatives as antibacterial agents in water catalyzed by RuCl_3·xH_2O

摘要

An efficient,convenient and environmentally benign one-pot multicomponent reaction for the preparation of pyrimido[4,5-b]quinoline derivatives as biologically,pharmacologically and antibacterially active products has been developed using RuCl_3·xH_2O as a reusable homogenous catalyst.Use of water as a green solvent,purification of products by non-chromatographic methods,reusability of transition metal homogenous catalyst,saving energy by employing multicomponent reactions,short reaction times and high yields,are some of the advantages of this process.