不同剂量替米考星对雏鸡心脏功能和呼吸的影响

摘要

本试验将70只45日龄的罗曼鸡随机分成对照组和试验Ⅰ～Ⅵ组,旨在探讨不同剂量替米考星对雏鸡心功能和呼吸的影响.结果显示,随着替米考星剂量的加大和给药时间的延长,V组死亡2只,Ⅵ组死亡4只；心率(HR)由增加到逐渐恢复,但5h后,Ⅵ组HR极显著低于对照组(P＜0.01)；左心室收缩压(LVSP)和左室内压最大变化速率(士dp/dtmax)呈逐渐下降趋势,左心室舒张末压(LVEDP)则逐渐升高,给药5h后,Ⅳ、Ⅴ和Ⅵ组LVSP极显著低于对照组、Ⅰ、Ⅱ和Ⅲ组(P＜0.01),Ⅴ和Ⅵ组极显著低于Ⅳ组(P＜0.01).Ⅱ组LVEDP显著高于对照组和Ⅰ组(P＜0.05),Ⅲ和Ⅳ组显著高于Ⅱ组(P＜0.05),极显著高于对照组和Ⅰ组(P＜0.01).Ⅴ、Ⅵ组极显著高于其他各组(P＜0.01)；Ⅰ～Ⅴ组呼吸逐渐加深加快.5h后,Ⅲ、Ⅳ和V组呼吸率显著高于对照组、Ⅰ和Ⅱ组(P＜0.05),但Ⅵ组呼吸率极显著低于Ⅲ、Ⅳ和V组(P＜0.01).提示替米考星在治疗雏鸡疾病时饮水安全使用剂量为400～600 mg/L,超过800mg/L时会对心肺功能产生明显影响.%70 of the 45-day Roman chickens were randomly divided into control group and experimental Ⅰ-Ⅵ groups to explore the impact of different doses of Tilmicosin on cardiac function and respiratory. With increasing dose and administration time of Tilmicosin,the results showed that 2 died in Ⅴ group and 4 died in Ⅵ group; heart rate(HR) increased and then gradually restored. However,after 5 h,HR of Ⅵ group was significantly lower than the control group (P<0. 01); left ventricular systolic pressure (LVSP) and maximum rate of change of left ventricular pressure (±dp/dtmax) decreased gradually,the left ventricular end diastolic pressure (LVEDP) is increased gradually. 5 h after administration,LVSP of Ⅳ, Ⅴ and Ⅵ group was significantly lower than the control group, Ⅰ, Ⅱ and Ⅲ group (P<0. 01) , Ⅴ and Ⅵ group was significantly lower than group Ⅳ (P<0. 01). LVEDP was significantly higher in group Ⅱ compared with the control group and Ⅰ group (P<0. 05) , Ⅲ and Ⅳ were significantly higher than group Ⅱ (P<0. 05) ,and significantly higher than group Ⅰ (P<0. 01). Ⅴ and Ⅵ group was significantly higher than other groups (P<0. 01); Ⅰ-Ⅴ group breathing gradually deepened and accelerated. After 5 h,the respiration rate of Ⅲ , Ⅳ and Ⅴ were significantly higher than the control group, Ⅰ and Ⅱ group (P<0. 05) ,but the respiratory rate of Ⅵ group was significantly lower than Ⅲ , Ⅳ and Ⅴ groups (P<0. 01). In the treatment of diseases of chickens, the safe drinking water dose of Tilmicosin is 400-600 mg/L,more than 800 mg/L,has a significant impact on cardiopulmonary function.