猪圆环病毒2型病毒样颗粒研究进展

摘要

猪圆环病毒2型（PCV2）是引起猪圆环病毒相关疾病的主要病原体，给养殖业造成重大经济损失。一直以来，对于PCV2的防控主要通过疫苗接种。目前使用的疫苗可大致分为全病毒灭活疫苗、嵌合病毒疫苗、重组亚单位疫苗三大类。病毒样颗粒（VLPs）作为一种伪病毒，以其高免疫原性、高安全性成为新型疫苗的研究热点。本文综述了VLPs在国内外的最新研究动态、研究和开发的意义，提出了VLPs作为一种基因转载工具，其研究为疫苗研发开拓了新的方向。%Porcine circovirus type 2(PCV2)is the main etiological agent of PCV2-associated diseases(PCVAD), causing enormous economic loss in pig industry. By far,vaccination is the major prevention and control measure against PCVAD. There are three kinds of vaccines applied in production at present,including inactivated whole-virus vaccine,mosaic virus vaccine and recombinant subunit vaccine. As a type of“fake”virus,PCV2 VLPs(virus-like particles)has become a hot research topic in the development of new vaccines,due to its advantages of better immunogenicity and higher security than traditional vaccines. In this article,the newest research trends and significance of research and exploitation were given a review. At the end,a conclusion was drawn:as a tool of genetic transfer vector,the research of VLPs would open up a new direction for the vaccine research and development.