2,5-二甲基-3,4-二氢-4-氧代喹唑啉的合成研究

摘要

对2,5-二甲基-3,4-二氢-4-氧代喹唑啉的合成进行了研究.以间甲基苯胺为原料经3步反应制得2-氨基-6-甲基苯甲酸,再环化生成2,5-二甲基-3,4-二氢-4-氧代喹唑啉.中间体及标题化合物结构经1HNMR确证.%Synthesis of 2, 5-dimethyl-3, 4-dihydro-4-oxo-quinazoline was studied in the paper. 2-Amino-6-methyl-benzoic acid was obtained via three steps with m-toluidine as starting material. Then, 2,5-dimethyl-3,4-dihydro-4-oxo-quinazoline was prepared by cyclization. The structures of intermediates and object compound were characterized by1HNMR.