氧化-还原生物催化偶联去消旋的研究进展

摘要

手性化合物是医药、农药和精细化学品的重要中间体，去消旋外消旋化合物是生产光学纯手性化合物的一个重要策略。氧化-还原生物催化偶联去消旋是目前制备手性化合物的重要方法，不仅简化了催化系统、提高了原子利用率和催化效率，而且经济环保。综述了氧化-还原生物催化偶联去消旋2-羟酸、氨基酸和醇的研究进展。%Chiral compounds are key intermediates for the synthesis of medicines,pesticides and fine chemi-cals.Deracemization of racemic compounds is an important way to obtain enantiopure chiral compounds.Derace-mization by biocatalytic redox cascade is an important method for preparation of chiral compounds due to its ad-vantages such as simple catalytic system,high atom utilization rate,high catalytic efficiency,economy and envi-ronmental protection.The research progress on deracemization of 2-hydroxy acids,amino acid and alcohol by biocatalytic redox cascade is summarized in this paper.