苄基三苯基季鏻盐的合成及其晶体结构和抗菌活性测定

摘要

合成了1种苄基三苯基季鏻盐---氯化苄基三苯基季鏻盐（[BzTPP]＋ Cl-）；利用元素分析、红外光谱、电子喷雾质谱和X射线单晶衍射对其进行了组成分析和结构表征；采用二倍稀释法测定了其抗菌活性，并与季鏻盐[BzTPP]2[CoCl4]和[BzTPP]2[MnCl4]进行了对比．结果表明，合成的季鏻盐[BzTPP]＋ Cl-属于正交晶系，Pbca空间群，晶胞参数为：a ＝1．3880（1） nm ，b ＝1．7170（2） nm ，c ＝1．8175（2） nm ，α＝β＝γ＝90°， V ＝4．1313（7） nm3，Z ＝8，Dc＝1．191 g/cm3，GOOF ＝1．002，R1＝0．0384，wR2＝0．1136．该季鏻盐由Cl-离子和[BzTPP]＋阳离子组成，阴、阳离子之间存在C -H⋯Cl氢键．与此同时，三种季鏻盐对大肠杆菌、金葡萄球菌及沙门氏菌均具有较好的抗菌活性．%A benzyltriphenylphosphonium salt ,[BzTPP]+Cl- ,was synthesized .The composi-tion and structure of as-synthesized product were analyzed by elemental analysis ,infrared spec-trometry ,electrospray mass spectrometry and single crystal X-ray diffraction .Moreover ,the antimicrobial activity of the product was determined by double dilution method and compared with that of [BzTPP]2 [CoCl4 ] and [BzTPP]2 [MnCl4 ] .Results show that as-synthesized prod-uct crystallizes in orthorhombic system and Pbca space group with cell parameters of a =1 .388 0(1)nm ,b = 1 .717 0(2) nm ,c = 1 .817 5(2) nm ,α= β= γ= 90° ,V = 4 .131 3(7) nm3 ,Z = 8 ,Dc= 1 .191 g/cm3 ,GOOF = 1 .002 ,R1 = 0 .038 4 ,and wR2 = 0 .113 6 .The unit cell of the compound contains [BzTPP]+ cation and Cl - anion ,and the anion and cation are linked via C -H⋯Cl weak hydrogen bonds .Besides ,the three kinds of benzyl triphenyl phos-phonium salts have good antibacterial activities against colibacillus ,staphylococcus aureus and salmonella .