4,6-二氯间苯二腈的合成

摘要

4,6-二氯间苯二腈是一个重要的医药化工中间体.本文设计了一条合成路线,以4,6-二氯苯甲酸为起始原料,经酰化、硝化、还原、重氮化等七步反应得到了目标化合物,其结构经MS和1 H NMR确证,该方法原料廉价易得,操作简单且收率较高,是一条适合工业化生产的合成路线.%2,4-dichlorobenzoic acid as a starting material,the important intermediate of 4,6-dichloroisophthalonitrile was prepared by seven steps:acylation,nitration,reduction,diazotization and so on. The stucture of target compound was characterized by MS and 1 HNMR. The raw materials used in this method were easy to obtain. The method had simple operation and high yield. It was a syn-thetic route suitable for industrial production.