研制了一种可移动的大气环境电喷雾离子化源,用其构建了位置可调的双路离子源,能分路、同时注入待测样品与标准.将其与四极杆-飞行时间(Q-TOF)质谱联用进行研究,证明其能独立、动态调节待测样品和标准的质谱信号或峰高比例,适于有限样晶质量的准确测定,质量误差一般＜2×10-6,最大不超过5×10-6.%Ambient electrospray guns were fabricated. They worked independently and could easily be set at any ambient inlet of a mass spectrometer( MS) such as Quadrupole-Time of Flight(Q-TOF) MS. By adjusting the distance and/or angle of their nozzles to the inlet, the signal intensity was dynamically regulated without any change of sample concentration and stop of the equipment. Using two of such guns, sample and calibrants were sprayed, ionized and introduced into the mass spectrometry separately but simultaneously. The peak ratio of sample to calibriant was dynamically adjusted to about 1: 1 and high accurate molecular mass was measured, with an error of -2. 7×10-6 which was -2. 9×10-6 by common internal calibrating determination. The method has been validated by a long time( >20 months) measure of different samples( >100) from various laboratories. The overall mass errors were kept within ±5×l0-6. It can be concluded that the method is facile, flexible, time- and cost-effective, and universally applicable.
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