1,2,3,4-四氢喹啉类化合物合成与应用的研究进展

摘要

1,2,3,4-四氢喹啉类化合物是治疗心血管病药物和染料的中间体。综述了1,2,3,4-四氢喹啉类化合物合成及应用的研究进展,分析比较了氢化反应、Diels-Alder反应、多步反应、多组分反应、多米诺反应等合成方法的优缺点,讨论了1,2,3,4-四氢喹啉类化合物在药物化学和染料合成领域的应用现状,并对其研究前景进行了展望：发展具有原子经济性合成方法及光学纯1,2,3,4-四氢喹啉类化合物的合成及应用。%1,2,3,4-tetrahydroquinoline derivatives are important intermediates of cardiovascular drugs and dye.The recent advances in the synthesis and application of 1,2,3,4-tetrahydroquinoline derivatives are reviewed in this paper.Different synthetic methods,including hydrogenation reaction,Diels-Alder reaction,multi-step reaction,multi-component reaction,and domino reaction,are compared,and the applications of 1,2,3,4-tetrahydroquinoline derivatives in medicinal chemistry and dye are also discussed.From the view of synthesis and practical applications,the research perspective of 1,2,3,4-tetrahydroquinoline derivatives is outlined in the end of this paper,which are the development of atom-economic methods and the synthesis and application of enantiomerically pure 1,2,3,4-tetrahydroquinoline derivatives.