近年来,随着纳米技术的发展,刺激响应性纳米纤维在药物控释、生物支架等生物医学方面的应用受到广泛关注.本文针对静电纺温敏纳米纤维(electrospun thermo-responsive nanofibers,ETRN)的制备方法和生物医学应用,对静电纺丝领域常用的温敏性高分子进行详细分类,选取具有代表性的聚N-异丙基丙烯酰胺和聚N-乙烯基己内酰胺,详细综述了基于静电纺丝技术制备温敏纳米纤维的化学改性及物理共混方法,对比以上两种方法的优缺点,并探讨温敏纳米纤维在药物控释、伤口敷料、生物触发器及细胞支架等领域的具体应用,点明静电纺温敏纳米纤维在发展过程中存在的问题,提出进一步提高其性能的解决方案,对其在智能催化、温控过滤等领域的应用前景进行展望.%The stimuli-responsive nanofibers have recently attracted much attention due to their potential biomedical applications,such as for drug controlled release and biological scaffolds. In this paper,the preparation methods and biomedical applications of electrospun thermo-responsive nanofibers were studied; thermo-responsive polymers commonly used in the field of electrospinning were classified in detail; the representative poly(N-isopropylacrylamide) and poly(N-vinylcaprolactam) were selected; the chemical modification and physical blending of thermo-responsive nanofibers based on electrospinning were reviewed,and then the above two methods were compared. The applications of thermo-responsive nanofibers in drug controlled release,wound dressing,biological trigger and cell scaffold,were discussed. The problems of the thermo-responsive nanofibers in development process were presented,and the solutions to further improve its performances were proposed; and its applications in intelligent catalysis,temperature-controlled filter were prospected.
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