Novel CHEK2 Mutation Identified Potentially Responsible for Early Onset of Breast Cancers in Chinese Population

摘要

Breast cancer is the most frequently diagnosed cancer and the second deadly tumor in females worldwide.On average,breast cancer patients in China are diagnosed of this disease 10 years earlier than their counterparts in US and Europe,and a higher percentage of them are diagnosed of this at 40 or earlier than in Caucasians.However,unlike in Caucasians,the occurrence of mutations in BRCA-1 and/or BRCA-2,which are widely believed to lead to the production of