源于牙源性角化囊性瘤的鳞状细胞癌(5例报道)

摘要

目的 探讨源于牙源性角化囊性瘤(keratocystic odontogenic tumors,KCOT)的鳞状细胞癌(SCC)的临床诊断及治疗.方法回顾5例由KCOT发展为SCC的患者病史,观察并记录每位患者的临床及影像学表现、治疗过程、组织病理表现及预后情况.结果 5例患者因KCOT接受治疗,在由KCOT转变为SCC 期间,主要为反复肿胀及疼痛,放射透射病变区范围扩大.病理上,所有患者由先前存在的伴有不全角化上皮的多囊性KCOT进展到具有典型病理表现的SCC.5例患者随访期间均死亡.结论 源于KCOT的SCC虽然罕见,但临床上不能忽视.长期严密观察、常规检查以及连续的影像学检查及活检可能有助于疾病的早期发现、早期诊断.%Objective To discuss the clinical diagnosis and trealmenl of squamous cell carcinoma arising (SCC) from keralocyslic odonlogenic Lumors ( KCOT) . Methods Five palienls with SCC that developed from KCOT were reviewed. The clinical and radiographic manifestation, therapy, histopalhology and the resulls of prognosis were observed and recorded for each palienl. Results Five palienls were originally trealed for KCOT. During the follow-up period when keralocyslic odonlogenic tumor developed to SCC, repealed swelling and pain were reporled and radiolucency area enlarged. All cases progressed from preexisling polycyslic KCOT wilh parakeralinized epilhelium lo SCC wilh typical pathological presentation. All five palienls died during the follow-up. Conclusion In KCOT cases, close follow-up, physical examinalions accompanied wilh serial radiographic imaging and biopsy may conlribule lo early deleclion and diagnosis of malignanl transformalion.