斑马鱼——髓鞘损伤与再生研究的理想动物模型

摘要

脱髓鞘疾病是以多发性硬化为主要表现的自身免疫性疾病,髓鞘脱失与再生的机制不明,利用动物模型进行深入研究是一个有效途径.新型模式动物——斑马鱼具有发育快速、胚胎透明、遗传学技术成熟等优势,通过构建转基因斑马鱼可以对细胞进行活体、动态观察和基因表达模式分析,是研究髓鞘损伤与再生的理想动物模型.%Multiple sclerosis is an immune-mediated disorder in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged,leading to demyelination and scarring as well as abroad spectrum of signs and symptoms.Zebrafish is an ideal model for investigating vertebrate demyelination and remyelination,due to the rapid external development and transparency of the embryos.Transgenic zebrafish allows visualization of cells in living zebrafish and provides a fast,real-time in vivo system for the analysis of gene expression patterns.