以硝酸胍和乙酸丙酮为原料,采用L9(34)正交实验法,以物料比、催化剂用量、反应时间为考察因素,优选2-氨基-4,6-二甲基的最佳合成工艺.结果表明,2-氨基-4,6-二甲基嘧啶的最佳合成工艺为:硝酸胍与乙酰丙酮用量比为6∶8,碳酸钾用量1.0 g,反应时间24h.%The synthesis technology of 2-amino-4,6-dimethyl pyrimidine was optimized using ureamine nitrate and acetic acetone as materials by L9 ( 34) orthogonal experiment. The influence of ratio of materials,catalyst dosage and reaction time were studied. The results showed the optimal conditions were as follows:the ratio of ureamine nitrate to acetic acetone was 6 ∶ 8 , potassium carbonate amount was 1. 0 g, reaction time was 24 h.
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