[目的]研究乙酰辅酶A羧化酶抑制剂对肥胖小鼠肥胖程度的影响。[方法]建立肥胖动物模型，然后随机分组，试验组以乙酰辅酶A羧化酶抑制剂按照50mg／（kg·bw·d）的剂量灌胃，对照组小鼠以去离子水灌胃。给药过程中，记录小鼠采食量和饮水量的变化情况。给药3周后，测定体重和体长。进行李氏指数的计算；称量脂肪，计算性器官周围脂肪占小鼠体重的比重；测定血清中胆固醇和甘油三酯的相对含量。[结果]乙酰辅酶A羧化酶抑制剂能抑制小鼠体重的增加，可减少肥胖小鼠的肥胖程度；能降低肥胖小鼠血清中的甘油三酯和胆固醇含量。[结论]乙酰辅酶A羧化酶抑制剂对肥胖小鼠有减肥作用，对小鼠的正常饮食没有明显影响。%[ Objective ] The research aimed to investigate the effect of the Acetyl-CoA carboxylase inhibitor on the obesity degree of obesity mice. [Method] The obesity animal model was established and mice were randomly divided. Mice in test group was fed with Acetyl-CoA carboxylase inhibitor with the dose of 50 mg/（kg, bw-d）by intragastric administration and mice in control group was treated with deionized water by intragastric administration. The changes of the feed intake and drinking amount of mice in the administration process were recorded. Mice were anatomize after administration three weeks.The body weight and body length were determined, and Lee＇s index was calculated. The fat was weighed and the proportion of the fat around the sexual organs in the body weight of mice was calculated. The relative contention of cholesterol and triglyceride in the serum was measured. [ Result ] Acetyl-CoA carboxylase inhibitor could inhibit the weight increase of mice, reduce the obese degree of obesity mice and decrease the contents of triglyceride and cholesterol in the serum of obesity mice. [ Conclusion ] Acetyl-CoA carboxylase inhibitor had the slimming action on obesity mice, but it had no obvious effect on the normal diet of obesity mice.
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