目的 探讨伐地那非联合表面麻醉剂治疗勃起功能障碍( ED) 伴有早泄患者的临床效果和安全性.方法 60例诊断为合并ED 的早泄患者,按需每次服用伐地那非20 mg,并将复方利多卡因乳膏于性交前均匀涂搽龟头处,共治疗12周.以阴道内射精潜伏期评价早泄治疗效果,并评估ED的总体疗效和治疗满意度,比较治疗前后的国际勃起功能指数-5(IIEF-5)评分.结果 治疗12周后,38例患者报告早泄有好转,有效率达63.3%,平均阴道内射精潜伏时间(IEL-T)由治疗前(0.43±0.31) min延长至(4.2±2.1) min;性交满意度评分由(7.6±2.5)分上升至(10.2±1.9)分,差异均有显著性(P< 0.01).勃起功能改善者共46例,总改善率为76.7%,IIEF-5评分从治疗前的平均11.2(11.2±4.9)分上升到治疗后的平均19.1(19.1±4.1)分,差异有显著性(P<0.01).不良反应共有8例(13.3 %),均为轻度或中度的,未经处理即自行缓解.结论 对合并ED的早泄病人,伐地那非联合表面麻醉剂能安全有效地改善其勃起功能,并能显著改善其早泄症状.%Aim To evaluate the efficacy and safety of vardenafil plus compound lidocaine cream in the treatment of premature ejacularntion (PE) complicated with erectile dysfunction (ED). Methods 60 patients of PE complicated by ED received vardenafil on-demand rnin doses of 20 mg plus compound lidocaine cream applied to glans before sexual intercourse for 12 weeks. Intravaginal ejaculatory latency rntime (IEL-T) and the intercourse satisfaction scores were recorded to evaluate the effect of PE treatment, as well as the general efficacy rnand satisfaction of ED treatment. And the differences of IIEF-5 before and after the treatment were compared. Results 38 patients had rntheir PE improved and the effective rate was 63.3％. 46 patients reported the improvement in erection and the percentage of erectile imrnprovement was 76.7％. Mild or moderate side effects were reported in 8 patients (13.3％), who recovered without any treatment. Conrnclusions To premature ejaculation patients with ED ,vardenafil plus compound lidocaine cream can safely and effectively improve their rnerectile function , and their PE symtoms could also be alleviated in the meantime.
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